On 14 February 2022, CLINUVEL announced the start of the second study in its DNA Repair Program. This mechanistic study (CUV151) will evaluate afamelanotide as a DNA repair agent in disease-free adults. In this second of a two-part series, CLINUVEL’s Head of Clinical Operations, Dr Pilar Bilbao, discusses the science behind the use of melanocortins in photoprotection and DNA repair.